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 Chiral Sulfide Catalysis for Desymmetrizing Enantioselective Chlorination

From : Our Group            Refresh Time : Jan. 2, 2019

     Congratulations! The publication of our group in Angew. Chem. Int. Ed, "Chiral Sulfide Catalysis for Desymmetrizing Enantioselective Chlorination" has been published recently (Qingxiang Cao, Jie Luo, and Xiaodan Zhao*Angew. Chem. Int. Ed., 2019, 58, 1315-1319 ).

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     Unprecendented chiral sulfide‐catalyzed desymmetrizing enantioselective chlorination is disclosed. Various aryl‐tethered diolefins and diaryl‐tethered olefins afforded teralins or tricyclic hexahydrophenalene derivatives bearing multiple stereogenic centers in high yields with excellent enantio‐ and diastereoselectivities. In contrast, tertiary amine catalyst (DHQD)2PHAL led to a diastereomer product. The products could be transformed to diverse compounds such as spiro N‐heterocycles.

     This research was rated as the inside back cover.

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