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 Chiral selenide-catalyzed enantioselective synthesis of trifluoromethylthiolated 2,5-disubstituted oxazolines

From : Our Group            Refresh Time : Jan. 2, 2019

     Congratulations! The publication of our group in Org. Biomol. Chem."Chiral selenide-catalyzed enantioselective synthesis of trifluoromethylthiolated 2,5-disubstituted oxazolines" has been published recently (Tian Qin, Quanbin Jiang, Jieying Ji, Jie Luo, and Xiaodan Zhao* Org. Biomol. Chem., 2019, 17, 1763-1766 ).

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     Chiral selenide-catalyzed enantioselective trifluoromethylthiolation of 1,1-disubstituted alkenes is disclosed. By this method, a variety of chiral trifluoromethylthiolated 2,5-disubstituted oxazolines were obtained in good yields with high enantioselectivities. This work not only provides a new pathway for the synthesis of chiral oxazolines, but also expands the library of chiral trifluoromethylthiolated molecules.

 

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