Organoselenium-Catalyzed Oxidative Allylic Fluorination with Electrophilic N–F Reagent
Congratulations! The publication of our group in ACS Catal., "Organoselenium-Catalyzed Oxidative Allylic Fluorination with Electrophilic N–F Reagent" has been published recently (Ruizhi Guo, Jiechen Huang, and Xiaodan Zhao* ACS Catal. 2018, 8, 926-930).
An efficient route of organoselenium-catalyzed oxidative allylic fluorination has been developed. In this transformation, bulky electrophilic fluorinating reagent N-fluoro-2,4,6-trimethylpyridinium triflate (TMFP-OTf) was employed as the oxidant and fluorine source. Notably, TEMPO as an additive affects the fluorination and leads to better substrate scope and excellent functional group tolerance. By this protocol, a variety of allylic fluorides were synthesized in good to excellent yields. The obtained allylic fluorides could be converted into vinyl fluorides efficiently in the presence of an appropriate base.
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